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1

Cytochrome P450-mediated drug interactions in COVID-19 patients: current findings and possible mechanisms

El-Ghiaty, Mahmoud A., Shoieb, Sherif M., El-Kadi, Ayman O.S.

Journal:

Medical Hypotheses

Year:

2020

File:

PDF, 516 KB

2020

2

Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases

Beshay N.M. Zordoky, Ayman O.S. El-Kadi

Journal:

Pharmacology & Therapeutics

Year:

2010

Language:

english

File:

PDF, 538 KB

english, 2010

3

Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line

Abdulqader A. Alhaider, Mohamed A.M. El Gendy, Hesham M. Korashy, Ayman O.S. El-Kadi

Journal:

Journal of Ethnopharmacology

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

4

Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism

Mohamed A.M. El Gendy, Badreldin H. Ali, Karim Michail, Arno G. Siraki, Ayman O.S. El-Kadi

Journal:

Journal of Ethnopharmacology

Year:

2012

Language:

english

File:

PDF, 593 KB

english, 2012

5

Development of a college-level assessment framework in line with international accreditation standards: A Middle Eastern perspective

Wilby, Kyle John, Zolezzi, Monica, Rachid, Ousama, El-Kadi, Ayman

Journal:

Currents in Pharmacy Teaching and Learning

Year:

2016

Language:

english

File:

PDF, 251 KB

english, 2016

6

Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies

Alrushaid, Samaa, Davies, Neal M., Anderson, Judy E., Le, Tyson, Yáñez, Jaime A., Maayah, Zaid H., El-Kadi, Ayman O.S., Rachid, Ousama, Sayre, Casey L., Löbenberg, Raimar, Burczynski, Frank J.

Journal:

Journal of Pharmacy and Pharmaceutical Sciences

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

7

The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: Evidence of tissue-specific enantioselectivity in microsomal metabolism

Negar Gharavi, Somayeh Sattari, Anooshirvan Shayeganpour, Ayman O.S. El-Kadi, Dion R. Brocks

Journal:

Year:

2007

Language:

english

File:

PDF, 637 KB

english, 2007

8

Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs

Jigar P. Patel, Hesham M. Korashy, Ayman O.S. El-Kadi, Dion R. Brocks

Journal:

Year:

2010

Language:

english

File:

PDF, 156 KB

english, 2010

9

NF-κB and AP-1 are key signaling pathways in the modulation of NAD(P)H:Quinone oxidoreductase 1 gene by mercury, lead, and copper

Hesham M. Korashy, Ayman O. S. El-Kadi

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

10

Down-regulation of aryl hydrocarbon receptor–regulated genes by tumor necrosis factor-α and lipopolysaccharide in murine hepatoma hepa 1c1c7 cells

Negar Gharavi, Ayman O.S. El-Kadi

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 217 KB

english, 2005

11

Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-α and lipopolysaccharide

Negar Gharavi, Ayman O.S. El-Kadi

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 436 KB

english, 2007

12

Cytochrome P-450 content and activity after cold storage of rat hepatocytes in university of wisconsin and sodium-lactobionate-sucrose solutions

Halima Serrar, Ayman El-Kadi, Patrick Du Souich, Pierre Haddad

Journal:

Liver Transplantation

Year:

1999

Language:

english

File:

PDF, 137 KB

english, 1999

13

The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat

Anooshirvan Shayeganpour, Hesham Korashy, Jigar P. Patel, Ayman O.S. El-Kadi, Dion R. Brocks

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 628 KB

english, 2008

14

Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells

Hesham M Korashy, Ayman O.S El-Kadi

Journal:

Year:

2004

Language:

english

File:

PDF, 809 KB

english, 2004

15

Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium

Reem H. Elbekai, Ayman O.S. El-Kadi

Journal:

Year:

2004

Language:

english

File:

PDF, 841 KB

english, 2004

16

Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells

Ghada Abdelhamid, Anwar Anwar-Mohamed, Osama A. Badary, Adel A. Moustafa, Ayman O.S. El-Kadi

Journal:

Cell Biology and Toxicology

Year:

2010

Language:

english

File:

PDF, 349 KB

english, 2010

17

The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine

Aws Alshamsan, Samar Hamdy, John Samuel, Ayman O.S. El-Kadi, Afsaneh Lavasanifar, Hasan Uludağ

Journal:

Year:

2010

Language:

english

File:

PDF, 888 KB

english, 2010

18

3-Methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats

Mona E Aboutabl, Beshay NM Zordoky, Ayman OS El-Kadi

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 536 KB

english, 2009

19

Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver

Ayman O S El-Kadi, Hélène Maurice, Huy Ong, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 314 KB

english, 1997

20

Modulation of aryl hydrocarbon receptor-regulated genes by acute administration of ammonium metavanadate in kidney, lung and heart of C57BL/6 mice

Ghada Abdelhamid, Issa E.A. Amara, Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Journal of Applied Toxicology

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

21

Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice

Anwar Anwar-Mohamed, Ghada Abdelhamid, Issa E. A. Amara, Ayman O. S. El-Kadi

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 650 KB

english, 2012

22

The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice

Ayman O.S. El-Kadi, Suleiman I. Sharif

Journal:

Pharmacology Biochemistry and Behavior

Year:

1996

Language:

english

File:

PDF, 704 KB

english, 1996

23

The influence of various experimental conditions on the expression of naloxone-induced withdrawal symptoms in mice

Ayman O.S. El-kadi, Suleiman I. Sharif

Journal:

General Pharmacology: The Vascular System

Year:

1994

Language:

english

File:

PDF, 472 KB

english, 1994

24

Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice

Ayman O.S. El-Kadi, Suleiman I. Sharif

Journal:

General Pharmacology: The Vascular System

Year:

1995

Language:

english

File:

PDF, 181 KB

english, 1995

25

The role of aryl hydrocarbon receptor and the reactive oxygen species in the modulation of glutathione transferase by heavy metals in murine hepatoma cell lines

Hesham M. Korashy, Ayman O.S. El-Kadi

Journal:

Chemico-Biological Interactions

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

26

The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+

Reem H. Elbekai, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 526 KB

english, 2005

27

The role of redox-sensitive transcription factors NF-κB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper

Hesham M. Korashy, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

28

Reply to Dvorak and Pavek, Letter to the Editor, regarding “The role of redox-sensitive transcription factors NF-κB and AP-1 in the modulation of Cyp1a1 gene by mercury, lead, and copper”

Hesham M. Korashy, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 119 KB

english, 2008

29

Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells

Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 861 KB

english, 2010

30

Acute Doxorubicin Toxicity Differentially Alters Cytochrome P450 Expression in the Kidney and Liver of Male Sprague Dawley Rats

Beshay Zordoky, Ayman El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 379 KB

english, 2010

31

Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-mediated Decrease of Cytochrome P450 1A1 (CYP1A1), CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes

Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 388 KB

english, 2010

32

Transcriptional Modulation of NAD(P)H: Quinone Oxidoreductase 1 by Mercury in Human Hepatoma HepG2 Cells

Issa E.A. Amara, Ayman O.S. El-kadi

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 397 KB

english, 2010

33

Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells

Issa E.A. Amara, Ayman O.S. El-Kadi

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 949 KB

english, 2011

34

Sustained interferon-γ delivery from a photocrosslinked biodegradable elastomer

Frank Gu, Husam M. Younes, Ayman O.S. El-Kadi, Ronald J. Neufeld, Brian G. Amsden

Journal:

Journal of Controlled Release

Year:

2005

Language:

english

File:

PDF, 470 KB

english, 2005

35

Cytochrome P450 enzymes: Central players in cardiovascular health and disease

Reem H. Elbekai, Ayman O.S. El-Kadi

Journal:

Pharmacology & Therapeutics

Year:

2006

Language:

english

File:

PDF, 448 KB

english, 2006

36

Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells

Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Toxicology and Applied Pharmacology

Year:

2009

Language:

english

File:

PDF, 772 KB

english, 2009

37

Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats

Beshay N.M. Zordoky, Anwar Anwar-Mohamed, Mona E. Aboutabl, Ayman O.S. El-Kadi

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 702 KB

english, 2010

38

Harman induces CYP1A1 enzyme through an aryl hydrocarbon receptor mechanism

Mohamed A.M. El Gendy, Ayman O.S. El-Kadi

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 949 KB

english, 2010

39

Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: A role of heme oxygenase

Hesham M. Korashy, Ayman O.S. El-Kadi

Journal:

Year:

2012

Language:

english

File:

PDF, 804 KB

english, 2012

40

H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart

Beshay N.M. Zordoky, Ayman O.S. El-Kadi

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 587 KB

english, 2007

41

Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells

Beshay N.M. Zordoky, Ayman O.S. El-Kadi

Journal:

Vascular Pharmacology

Year:

2008

Language:

english

File:

PDF, 502 KB

english, 2008

42

The Role of Dopamine in the Expression of Morphine Withdrawal

Ayman O.S El-Kadi, Suleiman I Sharif

Journal:

General Pharmacology: The Vascular System

Year:

1998

Language:

english

File:

PDF, 173 KB

english, 1998

43

Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct

Anna Eckers, Elisabeth Sauerbier, Anwar Anwar-Mohamed, Ingrit Hamann, Charlotte Esser, Peter Schroeder, Ayman O.S. El-Kadi, Lars-Oliver Klotz

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 954 KB

english, 2011

44

Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As3+, Cd2+ and Cr6+

Reem H. Elbekai, John Duke, Ayman O.S. El-Kadi

Journal:

Year:

2007

Language:

english

File:

PDF, 334 KB

english, 2007

45

Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: A mechanism of cancer chemoprotection

Hesham M. Korashy, Dion R. Brocks, Ayman O.S. El-Kadi

Journal:

Year:

2007

Language:

english

File:

PDF, 550 KB

english, 2007

46

Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells

Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Year:

2009

Language:

english

File:

PDF, 445 KB

english, 2009

47

Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms

Mohamed A.M. El Gendy, Anatoly A. Soshilov, Michael S. Denison, Ayman O.S. El-Kadi

Journal:

Food and Chemical Toxicology

Year:

2012

Language:

english

File:

PDF, 953 KB

english, 2012

48

Effect of mercury on aryl hydrocarbon receptor-regulated genes in the extrahepatic tissues of C57BL/6 mice

Issa E.A. Amara, Anwar Anwar-Mohamed, Ghada Abdelhamid, Ayman O.S. El-Kadi

Journal:

Food and Chemical Toxicology

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

49

Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2

Ayman El-Kady, Elena Klenova

Journal:

Year:

2005

Language:

english

File:

PDF, 606 KB

english, 2005

50

Induction of cytochrome P450 1a1 by the food flavoring agent, maltol

Anwar Anwar-Mohamed, Ayman O.S. El-Kadi

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

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